Publications by authors named "M Salvatierra"
Tertiary lymphoid structures (TLS) are lymphoid formations that develop in non-lymphoid tissues during chronic inflammation, autoimmune diseases, and cancer. Accurate identification and quantification of TLS in tissue can provide crucial insights into the immune response of several disease processes including antitumor immune response. TLS are defined as aggregates of T cells, B cells and dendritic cells.
View Article and Find Full Text PDFUnlabelled: The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces Programmed Death Ligand 1 (PD-L1), leading to suppression of anti-tumor immunity. Here we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of the RAS(ON) multiselective inhibitor RMC-7977 against KRASG12C-mutant non-small cell lung cancer (NSCLC) that shows resistance to traditional RASG12C inhibitors.
- It found that targeting RASGTP, either alone or alongside active RASG12C, leads to improved anti-tumor activity in various mouse models, indicating a more effective treatment strategy.
- Additionally, the research highlights a specific transcriptional program related to mucinous features in tumors, which may hinder the effectiveness of therapies like sotorasib or adagrasib in patients, presenting new insights for personalized treatment approaches.
The Bahía Blanca estuary (Argentina) has a morphological configuration resulting from hydrological and sedimentary processes related to Late Quaternary sea level changes. This estuarine system occupies a large coastal plain with a dense net of tidal channels, low-altitude islands and large intertidal flats. Little is known about the sedimentary units of the marine subbottom.
View Article and Find Full Text PDFBackground: Some studies have suggested that certain organochlorine (OC) compounds may impair neurodevelopment in animals and humans. The objective of this study was to investigate the association between prenatal exposure to an OC pesticide, mirex, and cognitive development in children at age of 4 years.
Methods: A population-based birth cohort in Granada (Spain) recruited between 2000 and 2002 was studied between 2005 and 2006, when the children were 4 years old.