Publications by authors named "M Salou"
Article Synopsis
- * A study involving 30 Togolese female sex workers analyzed 156 HPV genome sequences from cervical and anal swabs, revealing identical infections but varying genetic diversity across HPV types and sites.
- * Low-risk HPVs showed more mutations induced by APOBEC3 in the E4 and E6 genes compared to high-risk HPVs, which had fewer mutations, suggesting different cancer risk potentials among HPV types.
Article Synopsis
- Intestinal inflammation alters the composition and metabolism of gut microbiota, but the host's response to these changes is not fully understood.* -
- Mucosal-associated invariant T (MAIT) cells can detect metabolites from riboflavin-producing bacteria that increase during inflammation, promoting tissue repair in the intestines.* -
- Mice without MAIT cells showed higher susceptibility to colitis and related colorectal cancer, highlighting the significance of MAIT cells in responding to gut inflammation through bacterial metabolic pathways.*
Uveal melanoma (UM) is the most common cancer of the eye. The loss of chromosome 3 (M3) is associated with a high risk of metastases. M3 tumors are more infiltrated by T-lymphocytes than low-risk disomic-3 (D3) tumors, contrasting with other tumor types in which T cell infiltration correlates with better prognosis.
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- The study investigates the use of mucosal-associated invariant T (MAIT) cells to prevent or reduce graft-versus-host disease (GVHD), a significant complication after stem cell transplants.
- Researchers found that MAIT cells can inhibit the activation of alloreactive T cells in vitro and effectively delay or lessen the severity of GVHD in a preclinical mouse model when given shortly after PBMC infusion.
- The immunosuppressive effects of MAIT cells were linked to reduced levels of inflammatory cytokines like IFN-γ and TNF-α, while increasing anti-inflammatory IL-10, suggesting MAIT cells could be a promising treatment for GVHD and related conditions in future
γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets.
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