Short sirolimus half-life in pediatric renal transplant recipients on a calcineurin inhibitor-free protocol.

Immunosuppression with SRL may provide an opportunity to avoid long-term exposure to the nephrotoxicity of CNI. Thus, we have initiated an experimental protocol of IL-2r antibody induction, prednisone, MMF and SRL in pediatric renal transplant recipients (median age 15.5 yr, IQR 8.

The effects of acute renal failure on long-term renal function.

The relationship between acute renal failure (ARF) and long-term renal function remains unknown. We therefore undertook a study of patients at the Baltimore VA Hospital to examine the effects of a bout of acute renal injury on long-term renal function. We retrospectively reviewed the relationship between serum creatinine and time of observation for 6058 individuals who had values greater than 1.

The inevitability of renal function loss in patients with hypercreatinemia.

Unlabelled: Although it is anticipated that most patients with renal insufficiency will progress towards end-stage renal disease (ESRD) there have been few population-based studies to validate this assumption. We examined serial creatinines from 3,874 anonymous patients at an urban VA medical center who had a baseline creatinine of 1.4 mg/dl or greater to estimate the frequency of deterioration in renal function (DRF).

mRNA expression of the IGF system in the kidney of the hypersomatotropic rat.

Aim: To examine the response of the insulinlike growth factor (IGF) system in the kidney during a state of extreme growth.

Methods: We studied the mRNA expression of IGF-I, IGF-I receptor, and IGF-binding proteins (BP) using sensitive RNase protection assays following subcutaneous implantation of growth hormone pituitary cells (GH(3)) in rats.

Results: Within 5 weeks, the serum GH levels increased from 18.

Control of the epidermal growth factor receptor and its ligands during renal injury.

Aim: We studied control of the epidermal growth factor (EGF) receptor and its ligands during kidney injury, since they may be importantly involved in repair.

Methods: The folic acid model of renal injury was used in these studies. Messenger RNA (mRNA) was evaluated by solution hybridization.