Intrathecal pemetrexed in NSCLC patients with leptomeningeal metastasis.

Spread of lung cancer to the leptomeninges is rare and difficult to treat. Standard therapy comprises CNS-penetrant targeted agents with or without intrathecal chemotherapy. We performed a retrospective analysis of 16 patients with advanced NSCLC and leptomeningeal disease treated with intrathecal pemetrexed 50 mg.

Early initiation of ceftaroline-based combination therapy for methicillin-resistant Staphylococcus aureus bacteremia.

Purpose: Monotherapy with vancomycin or daptomycin remains guideline-based care for methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B) despite concerns regarding efficacy. Limited data support potential benefit of combination therapy with ceftaroline as initial therapy. We present an assessment of outcomes of patients initiated on early combination therapy for MRSA-B.

Biosorption of cobalt (II) from an aqueous solution over acid modified date seed biochar: an experimental and mass transfer studies.

Water pollution because of the presence of heavy metals remains a serious worry. The present work demonstrates the exclusion of cobalt ion (or Co(II)) from water using novel and cost-effective biosorbents. Initially, the biosorbent was chemically modified using orthophosphoric acid and then subjected to calcination to result acid modified date seed biochar (AMDB).