Publications by authors named "M Saiselet"
Background: The diagnosis of malignant thyroid nodules is mainly based on the fine-needle aspiration biopsy (FNAB). To improve the detection of malignant nodules, different molecular tests have been developed. We present a new molecular signature based on altered miRNA expressions and specific mutations.
View Article and Find Full Text PDFOur expanding knowledge of the interactions between tumor cells and their microenvironment has helped to revolutionize cancer treatments, including the more recent development of immunotherapies. Immune cells are an important component of the tumor microenvironment that influence progression and treatment responses, particularly to the new immunotherapies. Technological advances that help to decipher the complexity and diversity of the tumor immune microenvironment (TIME) are increasingly used in translational research and biomarker studies.
View Article and Find Full Text PDFArticle Synopsis
- MiR-7-5p is a downregulated miRNA in thyroid papillary carcinoma (PTC) that plays a role in tumor development by influencing cell proliferation.
- Overexpressing miR-7-5p in thyroid cell lines decreased their proliferation by modulating key signaling pathways like MAPK and PI3K.
- The study suggests that restoring miR-7-5p levels could be a potential therapeutic strategy for combating PTC, as its reduced expression is linked to increased levels of tumor-promoting factors like EGFR and IRS2.