Loss of H3K9 trimethylation leads to premature aging.

Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process.

Enhancement of yield and functional quality of Brassica microgreens: Effects of fertilization and substrate.

Brassica microgreens are rich in bioactive compounds, whose concentrations are influenced by environmental and cultivation conditions. This study evaluates the impact of different substrates and fertigation treatments, including sulfur, on the yield, morphology, and phytochemical profile of radish, red cabbage, white mustard, and red mizuna microgreens. Phytochemicals analyzed included total phenolic compounds (TPC), ascorbic acid (AA), and glucosinolates.

Annual Research Review: Adolescent social media use is not a monolith: toward the study of specific social media components and individual differences.

Social media have drastically changed the context of adolescent development. To date, the majority of research investigating the effects of these changes has measured time spent on social media, yielding inconclusive results-likely because this approach conceptualizes social media as a monolith. Social media experiences are complex and diverse, as are adolescents themselves.

Large cell neuroendocrine carcinoma in pancreatoblastoma with TP53 and SMAD4 mutations: a clinicopathologic study of a rare entity.

Pancreatoblastoma, a rare pancreatic tumor, exhibits diverse differentiation pathways, including acinar, ductal, and neuroendocrine lineages, often with distinct squamoid nests [3]. We present a notable case of pancreatoblastoma coexisting with large cell neuroendocrine carcinoma in a 10-year-old boy, presenting with abdominal discomfort, weight loss, and lesions in the pancreas, spleen, and liver visible on imaging. A liver biopsy revealed a poorly differentiated carcinoma with neuroendocrine features, while a splenic biopsy showed acinar cell differentiation, raising possible diagnoses of pancreatoblastoma or acinar cell carcinoma.

Diverse social media experiences and adolescents' depressive symptoms: the moderating role of neurobiological responsivity to rejected peers.

Adolescents' experiences with social media are complex and can impact their mental well-being differently. Our study aimed to understand how neurobiological sensitivities may moderate the association between different social media experiences and depressive symptoms. In a multiwave study, 80 adolescents (Mage = 13.