Publications by authors named "M Saint-Pierre"
Article Synopsis
- Research indicates that pathological forms of Tau are present in both Huntington's disease (HD) patients and animal models, suggesting HD may be seen as a secondary tauopathy alongside its main cause, a mutation in the huntingtin gene.
- Experiments with zQ175 mice showed that injecting Tau fibrils led to cognitive and anxiety-like issues, as well as an increase in harmful mutant huntingtin aggregates in their brains.
- Further studies with striatal cells revealed that Tau fibrils impair cell functionality and alter levels of heat shock proteins Hsp70 and Hsp90, indicating potential disruptions in protein quality control and suggesting a complex relationship between Tau and mutant huntingtin in HD.
JOURNAL/nrgr/04.03/01300535-202502000-00033/figure1/v/2024-05-28T214302Z/r/image-tiff There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson's disease after diagnosis. Given that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids, such as docosahexaenoic acid, and exercise in Parkinson's disease, we investigated whether both could synergistically interact to induce recovery of the dopaminergic pathway.
View Article and Find Full Text PDFSevere Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Are There Significant Differences Between Hospitalized and Emergency Department Patients?
Int J Chron Obstruct Pulmon Dis
January 2024
Rationale: Current guidelines define a severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as an increase in symptoms requiring hospital admission or emergency department (ED) visit. Little is known about whether or not subjects requiring hospitalization and those needing only ED care have similar patient profiles and if their clinical outcomes appear comparable.
Objective: The main goals of this study were to compare the demographic and clinical characteristics of patients treated for an AECOPD with an inpatient admission versus an ED visit and to review if hospital resource utilization was different between the 2 groups after discharge.
Background: Patients with chronic cough (>8 weeks) often remain symptomatic after appropriate investigations and therapeutic trials. Prior research has shown a benefit in certain individuals from pregabalin, but clinical improvement is quite unpredictable and variable.
Objective: The main objective of this study was to identify the demographic and clinical characteristics associated with a higher likelihood of cough improvement with a trial of pregabalin therapy.