Multi-Trait Index-Based Selection of Drought Tolerant Wheat: Physiological and Biochemical Profiling.

Drought is a detrimental abiotic stress that severely limits wheat growth and productivity worldwide by altering several physiological processes. Thus, understanding the mechanisms of drought tolerance is essential for the selection of drought-resilient features and drought-tolerant cultivars for wheat breeding programs. This exploratory study evaluated 14 wheat genotypes (13 relatively tolerant, one susceptible) for drought endurance based on flag leaf physiological and biochemical traits during the critical grain-filling stage in the field conditions.

Manuka Honey Inhibits Biofilm Formation and Reduces the Expression of the Associated Genes in .

Biofilms are major virulence factors formed by pathogenic bacteria to invade their host and maintain their colony. While biofilms usually develop on diverse solid surfaces, floating biofilms, also called pellicles, are formed at the air-liquid interface. To address the problem of biofilm formation by bacterial pathogens, honey has been extensively studied.

Metarhizium anisopliae (MetA1) seed priming improves photosynthesis, growth, plant defense and yield of wheat under drought stress.

Drought stress mitigation by endophytic microorganisms has the potential to enhance crop resilience. This research investigated the effects of M. anisopliae isolate MetA1 (MA) on drought tolerance in wheat plants by evaluating physiological, morphological, biochemical, and yield characteristics of two wheat genotypes, one being drought-susceptible (BR20) and another having drought withstanding capacities (BR28) in a pot experiment under moderate and severe drought conditions.

Novel Impact of Colchicine on Interleukin-10 Expression in Acute Myocardial Infarction: An Integrative Approach.

Inflammation plays a critical role in myocardial infarction as a critical process in the development of heart failure, involving the development of cardiac fibrosis. Colchicine is a well-established anti-inflammatory drug, but its scientific application in controlling post-acute myocardial infarction (AMI) inflammatory processes has not been established. IL-10 is a key cytokine in modulating inflammatory responses, underscoring its potential as a crucial therapeutic target of colchicine.

Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor.

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) constitute an appealing tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their physiological immaturity, resembling CMs in the late fetal stage, limits their utility. Herein, we have developed a novel, scalable cell culture medium designed to enhance the maturation of hPSC-CMs.