Publications by authors named "M Saif Siddiqui"
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs), long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). We discuss how ncRNAs affect gene expression in cancerous cells, the spread of cancer, and metastasis.
View Article and Find Full Text PDFBackground: Traditional nomograms can inform the presence of extraprostatic extension (EPE) but not laterality, which remains important for surgical planning, and have not fully incorporated multiparametric MRI data. We evaluated predictors of side-specific EPE on surgical pathology including MRI characteristics and developed side-specific EPE risk calculators.
Methods: This was a retrospective cohort of patients evaluated with mpMRI prior to radical prostatectomy (RP) in our eleven hospital healthcare system from July 2018-November 2022.
In this article, we present the concept of extended Seidel energy by employing a generalized extended matrix to study various molecular properties, including the Kovats retention index, boiling point, enthalpy of formation, entropy, acentric factor, and octanol-water partition coefficient. Our research broadens the scope of energy matrices in graph theory, with a particular emphasis on Sombor energy, reduced Sombor energy, average Sombor energy, Banhatti Sombor energy and reduced Banhatti Sombor energy. We examined the correlation of these graph-based energy descriptors with the thermodynamic properties of Benzenoid hydrocarbons (BHC), uncovering strong relationships between these indices and different molecular attributes.
View Article and Find Full Text PDFArticle Synopsis
- Appendiceal cancers, particularly mucinous cystadenocarcinoma, are rare and can cause serious complications like pseudomyxoma peritonei, leading to abdominal fluid accumulation called "jelly belly."
- A case of a young man with a persistent psoas abscess revealed mucinous adenocarcinoma with pseudomyxoma retroperitonei, emphasizing the need to consider malignancy in atypical abscesses.
- Early and accurate diagnosis is critical because these types of tumors can be misdiagnosed as common issues like abscesses, highlighting the importance of imaging and colonoscopy in identifying them.
Article Synopsis
- Advances in imaging techniques now allow for earlier and noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.
- Up to 60% of HCC cases show typical imaging features, while 40% do not, creating challenges for radiologists due to diverse morphologic subtypes and their unique molecular characteristics.
- The article focuses on unusual imaging presentations of HCC and discusses potential diagnostic pitfalls and conditions that may resemble HCC.