Publications by authors named "M Saied"
Background: Different molecular subtypes, including HER2-positive, have been identified in breast cancer. The overexpression of HER2 triggers downstream signaling pathways such as the PI3K/AKT/mTOR pathway. Until recently, trastuzumab has been used as a single HER2-targeted therapy in Egypt.
View Article and Find Full Text PDFDog overpopulation and stray dogs are global issues that are detrimental to public health and animal welfare. Thus, the goal of the current study was to provide alternatives for surgical castration. Therefore, calcium chloride was employed in this study, which might be an option for castration.
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- Psoriasis affects 2-3% of the global population and is treated with immunosuppressive drugs that can have serious side effects; Esculetin (Esc) is a natural alternative for treatment.
- The study aims to enhance the solubility of Esc by creating nanostructured lipid carriers (NLCs), which improve skin absorption and prolong the drug's presence on the skin.
- Results showed that Esc NLCs exhibited excellent entrapment efficiency and particle sizes that support effective skin delivery, leading to significant reductions in skin inflammation markers and highlighting their potential as a treatment for psoriasis.
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- Hepatic encephalopathy (HE) is a serious condition that links liver damage to brain dysfunction, often causing oxidative stress and inflammation.
- The study explored the protective effects of Mirabegron (Mira), a drug with antioxidant and anti-inflammatory properties, against liver and brain injuries induced by thioacetamide (TAA) in rats.
- Results showed that Mira improved motor skills, reduced ammonia levels, and lessened liver and brain damage by promoting antioxidant defenses and reducing inflammation and cell death while activating neuroprotective pathways.
This study aimed to investigate the protective effects of Rosemary ethanol extract (ROEE) on testicular damage induced by potassium Dichromate (PDC) in male rats regarding the signaling pathway of Nrf2 and its target genes and proteins. A total of 28 male rats were divided into four groups: control, PDC only (15 mg/kg b.w.
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