Publications by authors named "M Safavi-Naeini"
Article Synopsis
- The study investigates how different shielding strategies affect false positive rates in a neutron detection system for Neutron Capture Enhanced Particle Therapy (NCEPT).
- A Monte Carlo model was created to simulate the effects of neutron detection and various shielding configurations on a specific phantom setup.
- Results indicate that while shielding the detector crystal can worsen detection accuracy, adding a thin layer of GdO shield can enhance detection selectivity if boron is present in the detector's printed circuit boards.
Purpose: This study aims to validate the Light-Ion Quantum Molecular Dynamics (LIQMD) model, an advanced version of the QMD model for more accurate simulations in hadron therapy, incorporated into Geant4 (release 11.2).
Methods: Two sets of experiments are employed.
Article Synopsis
- The study compares the accuracy of different hadronic inelastic physics models in predicting positron-emitting fragments during carbon and oxygen ion therapy using various Geant4 Monte Carlo simulation toolkit versions.
- Three fragmentation models (BIC, QMD, INCL++) were tested across ten Geant4 versions with phantoms made of polyethylene, gelatin, or PMMA to evaluate positron annihilation and parent isotope production.
- Results showed no single model/version consistently predicted all outcomes best; BIC in Geant4 10.2 was most accurate overall, while QMD excelled in estimating peak positron yield depth and the point where yield drops to 50%.
Purpose: Neutron capture enhanced particle therapy (NCEPT) is a proposed augmentation of charged particle therapy that exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver a biochemically targeted radiation dose to cancer cells. This work is the first experimental demonstration of NCEPT, performed using both carbon and helium ion beams with 2 different targeted neutron capture agents (NCAs).
Methods And Materials: Human glioblastoma cells (T98G) were irradiated by carbon and helium ion beams in the presence of NCAs [B]-BPA and [Gd]-DOTA-TPP.
This work provides the first experimental proof of an increased neutron capture photon signal following the introduction of boron to a PMMA phantom during helium and carbon ion therapies in Neutron Capture Enhanced Particle Therapy (NCEPT). NCEPT leverages [Formula: see text]B neutron capture, leading to the emission of detectable 478 keV photons. Experiments were performed at the Heavy Ion Medical Accelerator in Chiba, Japan, with two Poly(methyl methacrylate) (PMMA) targets, one bearing a boron insert.
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