Publications by authors named "M Saez-de-Ocariz"
Background: Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare, usually fatal complication of blood transfusion.
Objective: To describe the characteristics of TA-GVHD in children.
Methods: The clinical records of pediatric patients diagnosed with TA-GVHD between January 2007 and December 2021 were reviewed.
Article Synopsis
- The study focuses on DOCK8 deficiency (DOCK8-Def), detailing the clinical, immunological, and genetic traits of affected patients.
- A review of 11 patients revealed that all exhibited eczema and recurrent infections, with common issues including bronchiectasis and food allergies, while some experienced rare complications like tuberculosis and neurological syndromes.
- The research emphasizes the importance of early diagnosis of DOCK8-Def, as it can lead to better treatment options such as hematopoietic stem cell transplantation (HSCT).
Article Synopsis
- - Ecthyma gangrenosum (EG) is a skin condition mainly caused by Pseudomonas aeruginosa infections in immunocompromised patients, presenting with reddish-purple spots that can progress quickly to severe skin ulcers.
- - A study analyzed 17 EG patients, revealing that many had underlying conditions like acute lymphoblastic leukemia; most presented with systemic symptoms like fever and pain, and P. aeruginosa was the most commonly isolated bacteria.
- - The findings suggest that if a patient shows fever and pain with rapidly worsening skin lesions, physicians should suspect EG and start treatment without waiting for lab results.