Publications by authors named "M Saeed Minhas"
Introduction: People with haemophilia A (PwHA) experience acute and chronic pain associated with reduced quality of life (QoL).
Aims: This post hoc analysis of pooled data from the HAVEN 1 (NCT02622321), 3 (NCT02847637), 4 (NCT03020160) and STASEY (NCT0319179) studies assessed the impact of emicizumab prophylaxis on pain-related QoL in PwHA.
Methods: PwHA received emicizumab during the four studies.
Article Synopsis
- Deferasirox (DFS) is an oral iron chelator used as a neuroprotectant for retinal diseases, but traditional oral administration has drawbacks like frequent dosing and first-pass metabolism.
- Researchers developed a nanosuspension of DFS that significantly improved solubility and stability, and loaded it into polymeric microneedles (MNs) for painless drug delivery to the eye.
- The microneedles showed effective scleral penetration and high drug deposition, indicating that this method is a promising alternative for delivering DFS to treat retinal conditions while maintaining cell viability and safety.
Hydrogels with the main objective of releasing mesalamine (5-aminosalicylic acid) in the colon in a modified manner were formulated in the present work using a free-radical polymerization approach. Different ratios of hyaluronic acid were cross-linked with methacrylic and acrylic acids using methylenebis(acrylamide). The development of a new polymeric network and the successful loading of drug were revealed by Fourier transform infrared spectroscopy.
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