One-pot four-component synthesis of novel isothiourea-ethylene-tethered-piperazine derivatives.

An efficient metal-free four-component approach for the synthesis of piperazine derivatives tethered to an isothiourea group through an ethylene link was developed. 1,4-Diazabicyclo[2.2.

Cold plasma treatment to prepare active polylactic acid/ethyl cellulose film using wheat germ peptides and chitosan.

In this study, the surface of the polylactic acid/ethyl cellulose (PLA/EC) blend film was modified by dielectric barrier discharge (DBD) plasma treatment to facilitate the spin-coating of chitosan (CH) and wheat germ bioactive peptides (PEP) obtained from enzymatic hydrolysis of defatted wheat germ protein isolate on the surface of the film. The suitable plasma treatment condition was 5 min at 20 kV according to ATR-FTIR, AFM, SEM, water angle contact, and water solubility results. Increasing the surface roughness and oxygen-containing functional groups (CO and -OH) improved coating by PEP and CH.

Synthesis and characterization of a new reusable calix[4]arene-bonded silica gel sorbent for antidiabetic drugs.

A novel calix[4]arene-bonded silica gel (C4BS) is prepared by covalent attachment of a calix[4]arene derivative to silica gel through a thiol-ene process. The structure and properties of C4BS were studied by Fourier Transform Infra-Red (FTIR) spectroscopy, thermal gravimetric analysis (TGA), elemental analysis (CHN), scanning electron microscopy (SEM), and surface area analysis (BET). In addition, the binding affinity of some antidiabetic drugs towards C4BS was investigated, by quantitative measurement of the drugs in aqueous solution using UV-visible spectroscopy.

Ultrasound mediation for efficient synthesis of monoarylidene derivatives of homo- and heterocyclic ketones.

Ultrasonic irradiation was efficiently used for high yield synthesis of monoarylidene derivatives of cyclic systems directly from the reaction of ketone with various aldehydes under solvent-free conditions. Reactions took place rapidly in the presence of catalytic amounts of pyrrolidine, while no significant formation of the undesired bis by-products was observed. Moreover, the procedure was applicable to both homo- and heterocyclic ketones.