c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device.

Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells.

Comparison of patients undergoing revision total hip arthroplasty and patients undergoing re-revision.

Objective: The aim of this study is to compare the demographic, clinical, and surgical characteristics of patients who underwent revision hip replacement surgery and those who underwent re-revision surgery. The secondary outcome is the investigation of the factors that play a role in estimating the time between primary arthroplasty surgery and revision surgery.

Patients And Methods: The patients who underwent revision hip arthroplasty in our clinic between 2010- 2020, patients with at least 2 years of follow-up, and who underwent re-revision surgery if needed were included.

functional models for human liver diseases and drug screening: beyond animal testing.

Liver is one of the most important and complex organs in the human body, being characterized by a sophisticated microarchitecture and responsible for key physiological functions. Despite its remarkable ability to regenerate, acute liver failure and chronic liver diseases are major causes of morbidity and mortality worldwide. Therefore, understanding the molecular mechanisms underlying such liver disorders is critical for the successful development of novel therapeutics.

Correlation of Measurements From Doppler Ultrasound and Optical Coherence Tomography in Glaucoma.

Objectives: To relate the changes in ocular structure and hemodynamic response in primary open-angle glaucoma (POAG).

Methods: Patients with POAG (n = 46) and control subjects (n = 53) were recruited. Retinal nerve fiber layer and ganglion cell complex were evaluated using optical coherence tomography (OCT).