Metal-Coordinated Histidine-Functionalized Redox-Responsive Polyethyleneimine as a Smart Gene Delivery Vector.

Despite significant advancements in gene delivery and CRISPR technology, several challenges remain. Chief among these are overcoming serum inhibition and achieving high transfection efficiency with minimal cytotoxicity. To address these issues, there is a need for novel vectors that exhibit lower toxicity, maintain stability in serum-rich environments, and effectively deliver plasmids of various sizes across diverse cell types.

Guidance on selecting and evaluating AI auto-segmentation systems in clinical radiotherapy: insights from a six-vendor analysis.

Artificial Intelligence (AI) based auto-segmentation has demonstrated numerous benefits to clinical radiotherapy workflows. However, the rapidly changing regulatory, research, and market environment presents challenges around selecting and evaluating the most suitable solution. To support the clinical adoption of AI auto-segmentation systems, Selection Criteria recommendations were developed to enable a holistic evaluation of vendors, considering not only raw performance but associated risks uniquely related to the clinical deployment of AI.

Commercial Cellulosic Paper-Based Solid Electrolyte for High-Temperature Lithium-Sulfur Batteries.

Solid-state lithium-sulfur (Li-S) batteries show promise for future electric mobility due to their high energy density potential. However, high internal impedance, Li polysulfide shuttling, and dendrite formation exist. Herein, we present a Li-rich cellulosic solid-state electrolyte (SSE) that, when paired with a sulfurized polyacrylonitrile (SPAN) cathode, leads to durable Li-S batteries for use in the room temperature to 50 °C range.

Evaluating Human-Robot Interactions to Support Healthy Aging-in-Place.

Declines in older adults' cognitive and physical health pose challenges to maintaining their independence. Robots can improve independent living and facilitate aging-in-place. Despite recent innovations in healthcare robotics, the use of robots has not advanced significantly among older adults.