Interstellar spectroscopic detection of HC(S)NC and DC(S)NC.

The detection of HC(S)CN in TMC-1 suggests that HC(S)NC may also exist. To aid in its possible detection, HC(S)NC and its deuterated isotopologue DC(S)NC were investigated via high-level ab initio methods, specifically CCSD(T) and CCSD(T)-F12. By utilizing multidimensional potential energy surfaces derived from explicitly correlated coupled-cluster calculations, we analyzed their geometrical parameters, vibrational frequencies, rotational constants, and a comprehensive set of spectroscopic constants generated via the vibrational second-order perturbation theory, vibrational self-consistent field, and vibrational configuration interaction theory(VCI) approaches.

[F]FDG PET/CT volumetric biomarkers for non-invasive prediction of HER2 expression in breast cancer patients.

Objectives: to investigate the capability of F-fluorodeoxyglucose positron emission tomography/computed tomography ([F]-FDG PET/CT) derived volumetric parameters to predict human epidermal growth factor receptor 2 (HER2) status in breast cancer patients.

Methods: retrospective study enrolled 47 female patients with breast cancer. All patients had pretreatment [F]-FDG PET/CT.

Potential cardioprotective effect of paroxetine against ventricular remodeling in an animal model of myocardial infarction: a comparative study.

Background: Post-myocardial infarction (MI) remodeling involves various structural and functional changes, such as inflammation and fibrosis. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is linked to the progression of cardiovascular diseases, including myocardial infarction. The inhibitory effects of paroxetine on GRK2 are recognized, yet its protective effect on post-MI remodeling has not been elucidated.

Development of silver-doped carbon dots sensor derived from lignin for dual-mode fluorometric and spectrophotometric determination of valsartan in a bulk powder and a commercial product.

Doping of carbon dots (CDs) with heteroatoms has garnered growing attention in recent years as a useful method of controlling their physicochemical properties. In this study, a new dual-mode sensor based on silver-doped CDs (AgCDs) derived from lignin was developed for fluorometric and spectrophotometric determination of valsartan (VAL). The analysis of AgCDs revealed a structure that closely resembled graphene oxide, with the successful doping of Ag.

Investigating the stability of a cerebral vasodilator drug using chromatographic methods: Evaluation of methods' practicality and environmental aspects.

A vinca alkaloid; vinburnine (VNB) is utilized as an effective vasodilator. As a cyclic amide-containing drug, it is likely susceptible to hydrolytic degradation. This study examined the degradation profile of VNB, findings indicated that VNB undergoes degradation solely in the presence of alkali, generating a carboxylic acid derivative (DEG).