Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.

The aim of our study was to investigate cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis in reproductive women with and without polycystic ovarian disease. We have studied 104 patients with a histological diagnosis of ovarian stromal hyperthecosis and stromal hyperplasia. Paraffin sections were stained by hematoxylin-eosin, von Gieson and immunohistochemistry for Bcl-2 (anti-apoptotic protein) and E-cadherin (cell adhesion marker).

Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis.

The aim of our study was to investigate proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis in reproductive women with and without polycystic ovarian disease. We have studied 104 patients with a histological diagnosis of ovarian stromal hyperthecosis and stromal hyperplasia. Paraffin sections were stained by hematoxylin-eosin, von Gieson and immunohistochemistry for Bcl-2 (anti-apoptotic protein) and Ki-67 antigen (proliferation marker).

[Clinical course and the effectiveness of conservative treatment of prolactin-secreting pituitary adenoma].

Forty-eight women with prolactin-secreting adenomas of the hypophysis and 22 patients with suspected microadenomas, aged 16 to 38, were examined. The highest blood prolactin levels and the most manifest symptoms were revealed in the patients with x-ray evidence of hypophyseal macroadenoma. Prolactin levels were lower, though still elevated, in the cases with small adenomas.

[Serotonin, histamine and catecholamine levels in patients with the hyperprolactinemia syndrome].

A total of 76 patients aged 18-39 with hyperprolactinemia were studied for the blood levels of serotonin and histamine and for the urinary ones of epinephrine, norepinephrine, dopa and dopamine. Blood levels of serotonin and histamine were recorded increased whereas the urinary levels of catecholamines were decreased. No correlation was shown between the intensity in the production of lactogenic hormone and those abnormalities found in the levels of the above mentioned amino groups.