Integrating GPT as an Assistant for Low-Cost Virtual Reality Escape-Room Games.

This work explores the integration of generative pretrained transformer (GPT), an AI language model developed by OpenAI, as an assistant in low-cost virtual escape games. The study focuses on the synergy between virtual reality (VR) and GPT, aiming to evaluate its performance in helping solve logical challenges within a specific context in the virtual environment while acting as a personalized assistant through voice interaction. The findings from user evaluations revealed both positive perceptions and limitations of GPT in addressing highly complex challenges, indicating its potential as a valuable tool for providing assistance and guidance in problem-solving situations.

Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs).

Fetal alcohol spectrum disorders (FASDs) are leading causes of neurodevelopmental disability but cannot be diagnosed early in utero. Because several microRNAs (miRNAs) are implicated in other neurological and neurodevelopmental disorders, the effects of EtOH exposure on the expression of these miRNAs and their target genes and pathways were assessed. In women who drank alcohol (EtOH) during pregnancy and non-drinking controls, matched individually for fetal sex and gestational age, the levels of miRNAs in fetal brain-derived exosomes (FB-Es) isolated from the mothers' serum correlated well with the contents of the corresponding fetal brain tissues obtained after voluntary pregnancy termination.

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury.

Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neuronal apoptosis after spinal cord transection in the lamprey. To elucidate the mechanisms in neuronal survival and axon regeneration, we have investigated whether these two effects are additive . We used lampreys as a spinal cord injury model.