Publications by authors named "M SCHIAVINA"
Intrinsically disordered proteins are abundant in eukaryotic systems, but they remain largely elusive pharmacological targets. NMR spectroscopy proved to be a suitable method to study these proteins and their interaction with one another or with drug candidates. Although NMR can give atomistic information about these interplays, molecular complexity due to severe spectral overlap, limited sample stability, and quantity remain an issue and hamper widespread applications.
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- Conformational variability of biological macromolecules is crucial for their functions and predicting their behavior in organism-wide studies.
- Various experimental and computational methods are used to understand this variability, leading to the creation of conformational ensembles with differing properties based on the reconstruction methods applied.
- The article proposes a geometrical framework to assess how well these predicted ensembles match with experimental data.
Previous research in India has identified urbanisation, human mobility and population demographics as key variables associated with higher district level COVID-19 incidence. However, the spatiotemporal dynamics of mobility patterns in rural and urban areas in India, in conjunction with other drivers of COVID-19 transmission, have not been fully investigated. We explored travel networks within India during two pandemic waves using aggregated and anonymized weekly human movement datasets obtained from Google, and quantified changes in mobility before and during the pandemic compared with the mean baseline mobility for the 8-week time period at the beginning of 2020.
View Article and Find Full Text PDFMonitoring sustainable urban development requires comparable geospatial information on cities across several thematic domains. Here we present the first global database combining such information with city extents. The Global Human Settlement Urban Centre Database (GHS-UCDB) is produced by geospatial data integration to characterise more than 10,000 urban centres worldwide.
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- Nuclear magnetic resonance (NMR) spectroscopy is a technique used to analyze biomolecules like proteins and nucleic acids with high precision, especially with the introduction of powerful 28.2 T magnets since 2019.
- This new ultra-high-field NMR allows researchers to study complex biomolecular structures, including flexible proteins known as intrinsically disordered proteins (IDPs) and regions (IDRs), which traditionally faced challenges due to crowded NMR spectra.
- The protocol offers methods to optimize high-field NMR experiments for IDPs/IDRs, including tailored experiments and strategies based on protein relaxation analysis, applicable to different molecular weights and complexities, as well as to lower field strengths.