Publications by authors named "M SAIGUSA"

Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus.

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Background: The prognosis of patients with coronavirus disease 2019 (COVID-19) was poor although its survival rate has been improved after the occurrence of the Omicron strain. Autoimmune pulmonary alveolar proteinosis (APAP), a lung disease caused by macrophage dysfunction induced by anti-granulocyte-macrophage colony-stimulating factor (GM-CSF)-neutralizing autoantibodies, is characterized by the deposition of proteinaceous material in the alveolar spaces. The clinical course of COVID-19 in patients with APAP remains unclear and this study aimed to clarify it.

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Background: We aimed to investigate risk factors predicting oxygen demand in COVID-19 patients.

Methods: Patients admitted to Shizuoka General Hospital with COVID-19 from August 2020 to August 2021 were included. First, we divided patients into groups with and without oxygen demand.

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A hyperspectral camera (HSC) is a camera with great potential to obtain spectral information at each pixel, together with spatial imaging. HSC fluorescence imaging enables the molecular aggregation dynamics of the evaporative crystallization process to be followed in real-time. The key intermediate liquid-like cluster state for the two-step nucleation mechanism is visualized by the fluorescence color changes of mechanochromic luminescent dibenzoylmethanatoboron difluoride derivatives.

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Article Synopsis
  • - The study investigated the real-world effectiveness of benralizumab, a drug for severe uncontrolled asthma, in 24 patients over 24 weeks, assessing various health metrics and treatment responses
  • - Results showed significant improvements in asthma control measures and a notable reduction in exacerbations, with 76.2% of patients meeting the criteria for treatment response after benralizumab administration
  • - The baseline levels of blood eosinophils and fractional exhaled nitric oxide (FeNO) were identified as predictive factors for the drug's effectiveness, suggesting their value in determining which patients may benefit the most from treatment.
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