Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome.

Introduction: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS.

Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight.

Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation.

Endocrine therapies and QTc prolongation.

QT interval represents the period between the initiation of depolarization and the end of repolarization of the ventricular myocardium. Excessive prolongation of this interval may drive to a potentially fatal ventricular tachyarrhythmia known as "torsades de pointes". Agents used to manage many endocrine disorders have been linked with QTc alterations.

Chronic complications in patients with newly diagnosed type 2 diabetes.

Introduction: The sly start of type 2 diabetes (DM2) very often complicates the patient before diagnosis. An early diagnosis of diabetes is strongly stressed nowadays so as to avoid or retard the progression of chronic complications. But the same emphasis is not put on the urgency of the diagnosis of these complications, at the same time as diabetes is diagnosed.