Publications by authors named "M S Younger"
Prospects on non-canonical olfaction in the mosquito and other organisms: why co-express?
Curr Opin Insect Sci
February 2025
The Aedes aegypti mosquito utilizes olfaction during the search for humans to bite. The attraction to human body odor is an innate behavior for this disease-vector mosquito. Many well-studied model species have olfactory systems that conform to a particular organization that is sometimes referred to as the 'one-receptor-to-one-neuron' organization because each sensory neuron expresses only a single type of olfactory receptor that imparts the neuron's chemical selectivity.
View Article and Find Full Text PDFSevere clinical phenotypes of heterozygous females with X-linked chronic granulomatous disease.
J Allergy Clin Immunol Pract
December 2024
Article Synopsis
- Female carriers of X-linked chronic granulomatous disease (XL-CGD) can experience serious health issues like infections and inflammatory disorders.
- Although males are more commonly affected, female carriers still require regular medical assessments and preventive treatments as needed.
- Continued monitoring and proactive care are crucial for managing the health of female XL-CGD carriers.
The mosquito is a prominent vector for arboviruses, but the breadth of mosquito viruses that infects this specie is not fully understood. In the broadest global survey to date of over 200 small RNA samples, we detected viral small interfering RNAs (siRNAs) and Piwi interacting RNAs (piRNAs) arising from mosquito viruses. We confirmed that most academic laboratory colonies of lack persisting viruses, yet two commercial strains were infected by a novel tombus-like virus.
View Article and Find Full Text PDFArticle Synopsis
- The CDC and ACIP endorse COVID-19 vaccination for patients with inborn errors of immunity (IEI), but there's limited knowledge on its safety and impact on infection severity in these patients.
- A study involving a registry of 1,245 IEI patients across 24 countries was conducted to gather data on vaccination frequency, safety, and effectiveness, revealing that 64.7% were vaccinated, primarily with mRNA vaccines.
- Results showed that vaccinated patients had significantly lower hospitalization and ICU admission rates when infected with COVID-19, indicating that vaccination is both safe and effective in reducing the severity of the disease in IEI patients.
Whole-Mount Immunofluorescent Labeling of the Mosquito Central Nervous System.
Cold Spring Harb Protoc
August 2024
Mosquito-borne disease is a major global public health issue. One path toward the development of evidence-based strategies to limit mosquito biting is the study of the mosquito nervous system-in particular, the sensory systems that drive biting behavior. The central nervous system of insects consists of the brain and the ventral nerve cord.
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