Early pneumonectomy for pulmonary mucormycosis.

Mucormycosis is a fungal infection caused by a rare pathogen most commonly affecting immunocompromised hosts. Successful treatment of pulmonary mucormycosis requires rapid diagnosis, reversal of predisposing factors, aggressive surgical excision, and antifungal therapy. We present a case of pulmonary mucormycosis affecting a young neutropenic male requiring a pneumonectomy.

Myoepithelial carcinoma of the lung: a review.

Primary myoepithelial carcinoma of the lung is a rare neoplasm with only 8 cases reported in the English literature to date. Myoepithelial carcinomas of the lung are thought to arise from submucosal bronchial glands and have morphologic features similar to their salivary gland counterparts. The pathologic features and immunohistochemical profile of this tumor have not yet been summarized in the literature.

Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer.

Background: Insulin-like growth factor 1 (IGF-I), IGF binding proteins (IGFBP) 1 to 7, and C-peptide have been postulated to predict survival in non-small cell lung cancer (NSCLC). Studying serum levels in NSCLC patients treated with surgical resection may provide information on the aggressiveness of tumors and be predictive of disease recurrence.

Methods: Immunobead assays were used to measure pretreatment serum levels of IGF-I, IGFBP1 to IGFBP7, and C-peptide in 100 NSCLC patients.

Biomechanical evaluation of parallel versus orthogonal plate fixation of intra-articular distal humerus fractures.

Background: Orthogonal and parallel plate constructs are used for fixation of intra-articular distal humerus fractures but optimal plate configuration remains controversial. The purpose of this study was to compare the biomechanical properties of orthogonal versus parallel plate constructs in a cadaver distal humerus fracture model.

Material And Methods: An intra-articular distal humerus fracture with a metaphyseal defect was created in 14 matched pairs of cadaver elbows.

A multi-analyte serum test for the detection of non-small cell lung cancer.

Background: In this study, we appraised a wide assortment of biomarkers previously shown to have diagnostic or prognostic value for non-small cell lung cancer (NSCLC) with the intent of establishing a multi-analyte serum test capable of identifying patients with lung cancer.

Methods: Circulating levels of 47 biomarkers were evaluated against patient cohorts consisting of 90 NSCLC and 43 non-cancer controls using commercial immunoassays. Multivariate statistical methods were used on all biomarkers achieving statistical relevance to define an optimised panel of diagnostic biomarkers for NSCLC.