A note from history: Landmarks in history of cancer, part 7.

In the 2 and half decades reviewed (1970-1995), research established that chromosomal translocation, deletion, and DNA amplification are prerequisites to cancerogenesis and that oncogenes, tumor-suppressor genes, growth factors, and cytokines play crucial roles in the pathomechanism of cancer. Human papillomavirus, human immunodeficiency virus, herpes virus, and hepatitis B virus were identified as cancer-causing viruses. Several laboratory tests were developed for the detection of primary and recurrent cancers, and cancer prevention by screening methods was popularized.

A note from history: Landmarks in history of cancer, Part 6.

In the 3 decades from 1940 to 1970, the United States became the nucleus for research, diagnosis, and treatment of cancer. The discovery of anticancer drugs, and the clinical demonstration that chemotherapy and radiation can cure cancer and have the ability to prevent recurrence of cancer, were incontrovertibly the most remarkable groundbreaking events. Consequently, the trend of less surgery and more multimodality therapy began.

Primary cutaneous adenomyoepithelioma.

Adenomyoepitheliomas are biphasic tumors composed of epithelial and myoepithelial components in varying proportions. They are commonly reported in the breast, uncommonly in salivary glands, and rarely in the lungs and vulva. Recent molecular analysis has shown that p27/kip-1 protein may play a role in their development.

Complex adnexal tumours of the skin: a report of three cases and review of literature.

Aims: Complex or composite adnexal tumours of the skin (CATS) are unusual neoplasms composed of two or more histopathologically distinct subtypes of appendageal neoplasms coexisting in a single cutaneous lesion. The authors report three examples of CATS, review literature and discuss their probable histogenesis.

Methods And Results: Of the three tumours described, one tumour showed a mixture of a proliferating pilar tumour and syringocystadenoma papilliferum, the second lesion was composed of a proliferating pilar tumour and tubulopapillary hidradenoma and the third tumour exhibited a syringocystadenoma papilliferum and tubulopapillary hidradenoma in combination.