Brain structural connectomic topology predicts medication response in youth with bipolar disorder: A randomized clinical trial.

Background: Response to pharmacotherapy varies considerably among youths with bipolar disorder (BD) and is poorly predicted by clinical or demographic features. It can take several weeks to determine whether medication for BD is clinically effective. Although neuroimaging biomarkers are promising predictors, few studies examined the predictive value of the brain connectomic topology.

Early death and intracranial hemorrhage prediction in acute promyelocytic leukemia: validation of a risk score in a chemotherapy plus ATRA cohort from an international consortium.

Not available.

HMA/VEN treatment modifications and associated outcomes in -mutant AML.

Hypomethylating agents (HMA) and venetoclax (VEN) are commonly used in patients with -mutated (m) acute myeloid leukemia (AML) ineligible for induction chemotherapy. While prior studies demonstrated high response and survival rates with HMA/VEN in m AML, the impact of treatment modifications in real-world settings is unclear. We retrospectively reviewed 89 m AML patients treated with HMA/VEN from January 2018 to June 2023.

Coping patterns associations with cognitive function in older adults.

Objective: Cognitive function may contribute to variability in older adults' ability to cope with chronic stress; however, limited research has evaluated this relationship. This study investigated the relationship between theoretically derived coping domains and cognitive function in 165 middle-to-older adults during the Omicron stage of COVID-19.

Method: Participants completed a clinical interview and self-report measures of health.