Publications by authors named "M S Stepanov"

Mitochondrial damage and associated oxidative stress are considered to be major contributory factors in cardiac pathology. One of the most potent naturally occurring antioxidants is taxifolin, especially in its water-soluble form. Herein, the effect of a 14-day course of the peroral application of the water-soluble taxifolin (aqTAX, 15 mg/kg of body weight) on the progression of ultrastructural and functional disorders in mitochondria and the heart's electrical activity in a rat model of myocardial injury induced with isoprenaline (ISO, 150 mg/kg/day for two consecutive days, ) was studied.

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The use of wireless sensor networks and the Internet of Things has increased dramatically in the last decade. The sensors measure the required parameters and send them to the data processing centers using one of the various wireless transmission technologies (often using cellular infrastructure) to make the appropriate decision. Files containing measurement information can arrive in bursts simultaneously, which is a critical issue to be aware of.

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The interaction of different dental alloys with the oral environment may cause severe side effects (e.g., burning sensation, inflammatory reactions, carcinogenesis) as a result of oral galvanism.

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High-Reynolds number homogeneous isotropic turbulence (HIT) is fully described within the Navier-Stokes (NS) equations, which are notoriously difficult to solve numerically. Engineers, interested primarily in describing turbulence at a reduced range of resolved scales, have designed heuristics, known as large eddy simulation (LES). LES is described in terms of the temporally evolving Eulerian velocity field defined over a spatial grid with the mean-spacing correspondent to the resolved scale.

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Article Synopsis
  • Cerebral ischemia affects around 15 million people globally each year, prompting the need for effective prevention and treatment methods in angiology and pharmacology.
  • Taxifolin (TAX) has cytoprotective properties, but its effectiveness is limited by poor solubility and difficulty crossing the blood-brain barrier; a water-soluble variant, aqua taxifolin (aqTAX), was studied for its protective effects on brain cells during ischemia-like conditions.
  • Findings revealed that aqTAX provided stronger cytoprotection than TAX, inhibiting cell necrosis and apoptosis more effectively, influencing gene expression related to oxidative stress and inflammation, and significantly reducing harmful calcium levels in neurons and astrocytes during ischemia. *
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