Publications by authors named "M S Starr"
Vacuole fusion is driven by SNARE proteins that require activation-or priming-by the AAA+ protein Sec18 (NSF) before they can bring membranes together and trigger the merger of two bilayers into a continuous membrane. Sec18 resides on vacuoles prior to engaging inactive cis-SNARE complexes through its interaction with the regulatory lipid phosphatidic acid (PA). Binding PA causes Sec18 to undergo large conformational changes that keeps it bound to the membrane, thus precluding its interactions with SNAREs.
View Article and Find Full Text PDFAs multiple front-line immune checkpoint inhibitor (ICI)-based combinations are approved for metastatic renal cell carcinoma, biomarkers predicting for ICI responses are needed past clinical prognostication scores and transcriptome gene expression profiling. Circulating markers represent opportunities to assess baseline and dynamic changes in immune cell frequency and cytokine levels while on treatment. We conducted an exploratory prospective correlative study of 33 patients with metastatic clear cell renal cell carcinoma undergoing treatment with ICIs and correlated changes in circulating immune cell subsets and cytokines with clinical responses to treatment.
View Article and Find Full Text PDFArticle Synopsis
- Renal dysfunction is linked to how quickly brain infarction progresses in patients who have suffered from anterior circulation large vessel occlusion (ACLVO) strokes, a topic not previously explored.
- A study analyzed data from 230 patients admitted with specific types of occlusions and measured their infarct growth rate (IGR) through imaging, categorizing them into fast or slow progressors based on this rate.
- Results indicated that those with higher serum creatinine levels and lower eGFR were more likely to be fast progressors and faced worse clinical outcomes and higher mortality rates after 90 days.