Publications by authors named "M S Sodhi"
Article Synopsis
- The study identified 46 metabolites in the milk of Ladakhi cows using advanced NMR spectroscopy, highlighting differences between colostrum, transition milk, and mature milk.
- Multivariate analysis showed that specific metabolites like UDP-galactose and creatine phosphate could effectively differentiate the stages of milk, indicating their importance in cell growth and defense.
- The findings underscore how certain metabolites in colostrum may support the growth and development of calves in the challenging high-altitude environment of Leh-Ladakh.
Bovine milk and colostrum play pivotal roles in the nutritional support of both human and bovine infants. Colostrum, the initial milk secretion, is crucial for neonatal growth, providing essential nutrients, growth factors, immunity, and defense mechanisms through a diverse array of bioactive compounds, including bioactive proteins and peptides. Peptidomics, leveraging the potential health benefits of peptides derived from food and body fluids, has become prominent in contemporary research.
View Article and Find Full Text PDFEffect of bovine beta-casomorphins on rat pancreatic beta cells (RIN-5F) under glucotoxic stress.
Biochem Biophys Res Commun
December 2024
Beta-casomorphins (BCMs) are the bio-active peptides having opioid properties which are formed by the proteolytic digestion of β-caseins in milk. BCM-7 forms when A1 milk is digested in the small intestine due to a histidine at the 67th position in β-casein, unlike A2 milk, which has proline at this position and produces BCM-9. BCM-7 has further degraded into BCM-5 by the dipeptidyl peptidase-IV (DPP-IV) enzyme in the intestine.
View Article and Find Full Text PDFPurpose: Fluoroquinolones are popular antibiotics used for a myriad of conditions including ocular procedures. Despite numerous case reports of acute pigmentary degeneration of the iris with fluoroquinolone use, a pharmacoepidemiological study has not been performed to examine and quantify this risk.
Design: Retrospective cohort study with a case-control analysis.
Prenatal stress increases the risk of neurodevelopmental disorders. NMDA-type glutamate receptor (NMDAR) activity plays an important pathophysiological role in the cortico-hippocampal circuit in these disorders. We tested the hypothesis that transcription of NMDAR subunits is modified in the frontal cortex (FCx) and hippocampus after exposure to prenatal restraint stress (PRS) in mice.
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