Publications by authors named "M S Sithara"
Kaempferol (KP), a GRAS-certified phytomolecule enrolled in Phase I trials, is reported with various biological effects including anticancer activity. However, its poor pharmacokinetic profile limits the translational utility. Studies indicate that liposomes incorporating cyclodextrin inclusion complexes improves the bioavailability of hydrophobic drugs.
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- * CRNMs utilize advanced biomaterials to achieve controlled release and stimuli sensitivity, specifically designed to address drug resistance in PDAC, while also considering pharmacokinetics and RNA interference for better therapeutic outcomes.
- * The review emphasizes the shortcomings of current animal models in accurately reflecting PDAC complexities and discusses past clinical failures, highlighting the potential of CRNMs to target critical pathways like Notch and Hedgehog for improved treatment strategies.
Background: Local anaesthetics are medications that cause numbness that can be reversed by applying them topically. Local anaesthetics are clinically used to control pain during minor surgeries or to treat other acute and chronic pain. The present investigation intended to investigate the anesthetic as well as analgesic potential of Injection Harsha 22, a novel polyherbal formulation in Wistar albino rats.
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