Genome-wide identification of copy number variation in diverse black pepper accessions.

A genome-wide resequencing analysis reveals the involvement of copy-number variation in black pepper accessions influencing advantageous agronomic traits and the evolution of elite genotypes with specific attributes. Black pepper (Piper nigrum L.) is renowned as a versatile seasoning, offers numerous health benefits, and possesses historical significance in the global spice trade.

Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy.

The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy.

Morpho-cultural, pathogenic, and genetic characterization of Indian isolates of causing charcoal rot in soybean.

, a devastating soil and seed-borne fungus causing charcoal rot in soybean, poses a significant challenge to soybean production and breeding programs across all major soybean-growing regions of India. Fifty-five isolates were collected from India's eight diverse soybean-growing agroecological regions. These isolates were examined for morpho-cultural, molecular, and pathogenic variability.

Frequency of adding salt is a stronger predictor of chronic kidney disease in individuals with genetic risk.

The incidence of chronic kidney disease (CKD) is increasing worldwide, but there is no specific treatment available. Therefore, understanding and controlling the risk factors for CKD are essential for preventing disease occurrence. Salt intake raises blood pressure by increasing fluid volume and contributes to the deterioration of kidney function by enhancing the renin-angiotensin system and sympathetic tone.

Plasma protein-based and polygenic risk scores serve complementary roles in predicting inflammatory bowel disease.

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), has a significant genetic component and is increasingly prevalent due to environmental factors. Current polygenic risk scores (PRS) have limited predictive power and cannot inform time of symptom onset. Circulating proteomics profiling offers a novel, non-invasive approach for understanding the inflammatory state of complex diseases, enabling the creation of proteomic risk scores (ProRS).