[X-ray contrast filler for balloons at endovascular surgery (20 years of experience with original balloon filler)].

In 1984, the authors designed a X-ray contrast balloon filler polyacryl amide gel (PAAG) that has a polymerization rate of 1-3 min. PAAG has been used to fill over 5000 balloons for nearly 20 years. With this filler, recurrent anastomoses reduced by 1.

[Lipid peroxidation in the cyst fluid of craniopharyngiomas].

Comparing of the craniopharyngiomas cyst fluid, collected during the surgery, with blood plasma revealed significantly enhanced lipid peroxidation and lactate accumulation in tumour cysts contents. These processes were usually more prominent in endosuprasellar than in suprasellar craniopharyngiomas. The maximum of free radical formation in conjunction with the lowest level of malondialdehyde (MDA) was observed in primary tumours with relatively high proliferation rate.

[Lipid-bound sialic acids in the blood of patients with brain diseases].

The results of studies of the blood levels of lipid-bound sialic acids (LBSA) in patients with various brain tumors, subarachnoidal hemorrhage (SAH) caused arterial aneurysmal rupture and in those with brain injury (BI) are analyzed. Significant differences were found in blood LBSA levels in patients with hemispheric tumors and in those with chiasmal sellar ones. The findings suggest that blood LBSA levels cannot be a marker for brain tumors as the blood of patients with benign chiasmal sellar tumors shows high LBSA levels reaching those in patients with malignant hemispheric tumors.

[The role of biochemical processes in the pathogenesis of complicated hydrocephalus in children].

Spinal fluid radical formation levels, malonic dialdehyde concentrations, and intrinsic antioxidative activity were studied in 84 patients with hydrocephalus. The findings suggest that there is a considerable activation of free radical reactions and lipid peroxidation, as well as a reduction in antioxidative activity. These changes were most drastically profound in children with inflammation-complicated hydrocephalus with spinal fluid hemorrhagic changes in particular.

[Cerebral hemodynamics and metabolism in the acute stage of cerebral aneurysm rupture].

The relationship between lipid peroxidation products and the severity of arterial spasm was studied in 86 patients. For this, the level of radical production, the content of the end lipid peroxidation product malonic dialdehyde and the overall antioxidative activity of lumbar cerebrospinal fluid were determined during 24-hour Doppler monitoring of blood flow in the middle cerebral and internal carotid arteries. Following subarachnoidal hemorrhage, the activation of lipid peroxidation processes was shown to correlate with the severity of arterial spasm and it is likely to contribute to the development of late ischemias.