Publications by authors named "M S Pitiakoudis"
Background: The mechanism by which laparoscopic operations induce lower post-operative inflammatory response compared to open surgery was investigated with regard to the effect of the type of gas environment.
Methods: Rats were subjected to midline laparotomy at either CO (group CO) or room-air environment (group Air) or to anesthesia only (group Control) under atmospheric pressure conditions. At various timepoints after surgery (1, 3, 6, 24, or 48 h), the expression of inflammation biomarkers interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), and nuclear factor-κΒ (NFκΒ) were assessed immunohistochemically in tissue samples excised from the liver, intestine, and kidneys, accompanied by histopathologic analysis, and their levels were measured by ELISA in blood samples.
Article Synopsis
- * EPs can appear in various body parts, including the lungs, breasts, and abdominal organs, making them tough to diagnose due to their similar imaging characteristics to other conditions.
- * The review highlights the importance of imaging for detecting EPs, but emphasizes that a histological confirmation is essential for an accurate diagnosis, especially for patients with a history of multiple myeloma, as timely diagnosis can greatly improve
Tumor-infiltrating lymphocytes, PD-L1, and MMR-deficiency combined characterization may identify subgroups of rectal cancer patients who would benefit from immunotherapy.
Immunobiology
November 2023
Article Synopsis
- Mismatch repair deficiency, immunological fertility, and PD-L1 status are crucial factors for understanding how rectal cancer tumors respond to immunotherapy and their overall prognosis.
- In a study of advanced rectal cancer patients, higher tumor-infiltrating lymphocyte (TIL) density correlated with better survival outcomes, while cancer cell PD-L1 expression presented mixed effects on prognosis.
- The findings suggest that patients with high TIL density combined with high PD-L1 expression might benefit from targeting anti-PD-1/PD-L1 therapies, along with those with mismatch repair deficiency.
Postoperative air leak (PAL) is a frequent and potentially serious complication following thoracic surgery, characterized by the persistent escape of air from the lung into the pleural space. It is associated with extended hospitalizations, increased morbidity, and elevated healthcare costs. Understanding the mechanisms, risk factors, and effective management strategies for PAL is crucial in improving surgical outcomes.
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