Publications by authors named "M S Pillai"
Purpose: To assess the safety and efficacy of non-penetrating deep sclerectomy (NPDS) in advanced open-angle glaucoma patients.
Design: Retrospective observational study.
Methods: Forty-two eyes of 38 patients with advanced glaucoma who underwent NPDS surgery combined with mitomycin-C with or without phacoemulsification were evaluated for up to 12 months at a tertiary eye care center in South India.
Objective: To assess the accuracy of a large language model (LLM) in measuring clinician adherence to practice guidelines for monitoring side effects after prescribing medications for children with attention-deficit/hyperactivity disorder (ADHD).
Methods: Retrospective population-based cohort study of electronic health records. Cohort included children aged 6 to 11 years with ADHD diagnosis and 2 or more ADHD medication encounters (stimulants or nonstimulants prescribed) between 2015 and 2022 in a community-based primary health care network (n = 1201).
Article Synopsis
- Bloodborne pathogens (BBPs) are a serious global health threat affecting both humans and animals, with notable risks for healthcare workers who face potential exposure.
- The paper critiques traditional detection methods like PCR and ELISA, pushing for new detection technologies enhanced by advances in sensor tech.
- It aims to educate on bloodborne infections, detailing their transmission patterns and emphasizing the need for improved management and detection strategies.
Article Synopsis
- TDP-43 aggregation is linked to neurodegenerative diseases like ALS, with specific mutations (D169G and P112H) affecting its stability and aggregation.
- The P112H mutant exhibits higher chemical stability at physiological pH but forms amyloid fibrils more rapidly at low pH compared to TDP-43 and D169G.
- This study combines experimental and simulation techniques to reveal how the mutations influence the conformational changes and aggregation process of TDP-43, highlighting the role of ionic strength and charge in the aggregation behavior.