Bioanalytical method development, pharmacokinetic evaluation, platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor.

Background: Ticagrelor, a potential antithrombotic drug indicated for cardiovascular events with acute coronary syndrome, has been restricted from its oral use due to poor aqueous solubility. The present investigation aimed to develop validated bioanalytical method for the analysis of plasma samples for improving the oral bioavailability of Ticagrelor. Additionally, evaluation of the improved antiplatelet activity of the Ticagrelor formulation compared to the marketed formulation.

Association of trace element levels in primary teeth and occurrence of Cleft lip and/or palate.

Background: Cleft lip and/or palate (CL/CP) are common congenital anomalies with multifactorial origins, potentially influenced by environmental factors, including multi-trace metal exposure. Primary teeth, which form in utero, offer a unique biomatrix for assessing early-life metal exposure, yet remain underexplored in CL/CP research.

Objective: This case-control study aimed to investigate the association between multi-trace metal exposure and CL/CP occurrence by analyzing primary teeth using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

Impact of Lefort III/ monobloc advancement on midface growth in children with syndromic craniosynostosis: A systematic review.

Syndromic craniosynostosis is a complex condition involving the craniofacial skeleton, often requiring surgical midface advancement (SMA) to address functional and aesthetic concerns. A systematic review of literature was conducted on the impact of Lefort III/monobloc advancement on midface growth of children with syndromic craniosynostosis. Comprehensive search of multiple databases yielded 21 studies that met the inclusion criteria.

Heart rate variability biofeedback in a global study of the most common coherence frequencies and the impact of emotional states.

This global study analyzed data from the largest dataset ever studied in the Heart Rate Variability (HRV) biofeedback field, comprising 1.8 million user sessions collected from users of a mobile app during 2019 and 2020. We focused on HRV Coherence, which is linked to improved emotional stability and cognitive function.

Sequence and Chronology of Permanent Teeth Eruption in 5-18-Year-Old School Children of Chennai and the Influence of Sex, BMI, and Socio-Economic Status.

Objectives: This study aimed to determine the sequence and eruption chronology of permanent teeth in school children and adolescents of Chennai and compare the findings with an existing standard table. Additionally, the study also attempted to explore the influence of sex, body mass index (BMI), and socioeconomic status (SES) on tooth eruption patterns.

Methods: A cross-sectional study was designed, and 12,650 children aged 5-18 years were selected from thirty-five schools using a multistage random sampling method.