Publications by authors named "M S Muhlebach"
Background: Infection control guidelines for cystic fibrosis (CF) stress cleaning of environmental surfaces and patientcare equipment in CF clinics. This multicenter study measured cleanliness of frequently touched surfaces in CF clinics using an ATP bioluminescence assay to assess the effectiveness of cleaning/disinfection and the impact of feedback.
Methods: Eight surfaces were tested across 19 clinics (10 pediatric, 9 adult) over 5 rounds of testing.
Article Synopsis
- CF care guidelines suggest using chronic inhaled antibiotics to treat lung infections caused by Pseudomonas aeruginosa, but these treatments can be expensive and time-consuming.
- A study examined the prevalence of different infection statuses among people with cystic fibrosis (pwCF) and identified factors that influenced antibiotic prescriptions from 2011 to 2019.
- Results showed a decrease in chronic and intermittent P. aeruginosa cases, but increased antibiotic prescriptions for these groups, while prescriptions for patients without P. aeruginosa infections declined, indicating shifting healthcare trends over time.
Article Synopsis
- TMPRSS2 is an accessory protease that increases the entry of SARS-CoV-2 into cells expressing ACE2, impacting how the virus interacts with host cells during infection.
- Experiments showed that TMPRSS2 enhances the internalization of the virus, improves early replication rates, and modifies immune responses, depending on the virus variant.
- The study reveals that TMPRSS2 not only affects viral uptake and replication but also leads to increased cell death and drives the evolution of viral mutations, linking these processes to the effectiveness of the host's immune response.
Background: Whether there is any benefit in integrating culture-independent molecular analysis of the lower airway microbiota of people with cystic fibrosis into clinical care is unclear. This study determined the longitudinal trajectory of the microbiota and if there were microbiota characteristics that corresponded with response to treatment or predicted a future pulmonary exacerbation.
Methods: At least one sputum sample was collected from 149 participants enrolled in this prospective longitudinal multi-centre study and total bacterial density and microbiota community measurements were determined and compared with clinical parameters.
Background: Care guidelines for cystic fibrosis (CF) have been developed to enhance consistent care and to improve health outcomes. We determined if adherence to CF care guidelines predicted P. aeruginosa incidence rates (Pa-IR) at U.
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