Publications by authors named "M S McHale"
FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.
View Article and Find Full Text PDFAlGrow software provides a graphical interface to define target color volumes as hulls in color space and applies them to image segmentation and growth rate analysis across a multiplexed image series.
View Article and Find Full Text PDFArticle Synopsis
- - The NCCN Guidelines outline a comprehensive approach to diagnosing, staging, and treating ovarian, fallopian tube, and primary peritoneal cancers.
- - Recent developments in the use of PARP inhibitors, both as maintenance therapy and standalone treatments, have significantly influenced the recommendations in these guidelines.
- - These insights highlight the collaborative effort among experts to continuously update treatment protocols based on the latest research in ovarian cancer therapies.
Intraduodenal fecal microbiota transplantation ameliorates gut atrophy and cholestasis in a novel parenteral nutrition piglet model.
Am J Physiol Gastrointest Liver Physiol
November 2024
Article Synopsis
- Total parenteral nutrition (TPN) is a lifesaving IV feeding method but can cause serious side effects like gut microbial changes and liver injury.
- A study involving 31 piglets tested the effects of transferring fecal microbiota from healthy pigs to those on TPN, with various groups including a control, TPN alone, TPN with antibiotics, and TPN with fecal transplant.
- The results showed that fecal microbiota transplant (FMT) helped prevent gut atrophy, liver injury, and harmful microbial changes seen in TPN, suggesting that gut microbes could be critical for developing new treatments.
Unlabelled: Sea lettuce () is recognised for its potential in food, pharmaceutical, nutraceutical, biorefinery and bioremediation industries and is increasingly being cultivated. The requirements of those industries vary widely in terms of biomass composition. biomass composition and growth is known to be directly influenced by environmental factors, e.
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