Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.

The vasodilator hydralazine (HYZ) has been used clinically for ∼ 70 years and remains on the World Health Organization's List of Essential Medicines as a therapy for preeclampsia. Despite its longstanding use and the concomitant progress toward a general understanding of vasodilation, the target and mechanism of HYZ have remained unknown. We show that HYZ selectively targets 2-aminoethanethiol dioxygenase (ADO) by chelating its metal cofactor and alkylating one of its ligands.

Attempted ablation of an orbital cyst in a dog with 1% polidocanol using fluoroscopy and contrast cystography.

A 4-year-old female spayed mixed-breed dog received enucleation surgery of the right eye in 2018 following the diagnosis of glaucoma. The patient was presented in 2021 for recurrent swelling of the right orbit. Ultrasound confirmed the presence of a cystic structure, and chemical ablation with 1% polidocanol (compounded, Stokes Pharmacy, Mt.

The Trifecta of Industry, Academic, and Health System Partnership to Improve Mental Health Care Through Smartphone-Based Remote Patient Monitoring: Development and Usability Study.

Background: Mental health treatment is hindered by the limited number of mental health care providers and the infrequency of care. Digital mental health technology can help supplement treatment by remotely monitoring patient symptoms and predicting mental health crises in between clinical visits. However, the feasibility of digital mental health technologies has not yet been sufficiently explored.

Diversity in crisis: The impact of race and ethnicity on failure to rescue among geriatric trauma patients over the years.

Background: Failure to rescue (FTR) is an indicator of the quality of care provided by trauma centers. The aim of this study was to examine the trends of FTR incidence in geriatric trauma patients over the years and to determine whether race, ethnicity, and sex impact the FTR incidence.

Methods: This is a retrospective analysis of the American College of Surgeons Trauma Quality Improvement Program database over 4 years (2017-2020).