Publications by authors named "M S Lonardo"
The historically most commonly used preoperative radiotherapy regimen for soft tissue sarcomas (STSs) consists of 50 Gray (Gy) delivered in 25 fractions over 5 weeks, achieving excellent local control, but with significant challenges due to prolonged treatment duration and early side effects. Reducing therapy duration while maintaining optimal local and distant control would be highly beneficial for patients. We aimed to investigate the outcome of an ultrahypofractionated radiotherapy (uhRT) regimen which may represent a shorter and more patient-friendly alternative.
View Article and Find Full Text PDFBackground/objectives: One of the main culprits of the obesity epidemic is the obesogenic food environment, which promotes the consumption of ultra-processed foods (UPFs) that are highly palatable, have low nutritional quality and a high caloric impact and are economical and ready to use. This monocentric retrospective study explored the association between UPFs, obesity and adiposity measurements among adults living with obesity in Southern Italy.
Methods: According to their Body Mass Index (BMI) values, 175 participants (63M) were recruited and stratified into three groups.
Acute and chronic hypertension causes cerebral vasculopathy, increasing the risk of ischemia and stroke. Our study aimed to compare the effects of arterial pressure reduction on the pial microvascular responses induced by hypoperfusion and reperfusion in spontaneously hypertensive Wistar rats, desamethasone-induced hypertensive Wistar rats and age-matched normotensive Wistar rats fed for 3 months with a normal diet or normal diet supplemented with L-arginine or Taurisolo or L-arginine plus Taurisolo. At the end of treatments, the rats were submitted to bilateral occlusion of common carotid arteries for 30 min and reperfusion.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the relationship between skeletal muscle mass and plasma lipid levels in healthy young adults aged 18-45, analyzing data from 450 subjects over a 15-year period.
- - Researchers measured skeletal muscle mass using bioelectrical impedance analysis and compared lipid profiles, revealing that overweight and obese individuals had higher total cholesterol, LDL cholesterol, and triglycerides but lower HDL cholesterol than those of normal weight.
- - The findings indicated that in obese females, lower skeletal muscle mass correlated with reduced HDL cholesterol, implying that muscle mass changes in obesity may negatively impact lipid profiles, particularly HDL levels.
Article Synopsis
- The rising prevalence of chronic kidney disease (CKD) among the elderly poses challenges due to conflicting dietary recommendations: low-protein diets are advised for CKD while higher protein intake is suggested for preventing malnutrition in older adults.
- This study investigates the effects of a low-protein adequate energy (LPAE) diet on nutritional status and metabolic issues in elderly CKD patients (stages 3-5) over six months.
- Results indicate that compliant patients on the LPAE diet saw improvements in body composition and metabolic parameters without increased malnutrition risk, highlighting its potential as a safe dietary approach for this population.