Publications by authors named "M S Lehtinen"

Article Synopsis
  • 2'-fucosyllactose (2'-FL) in human milk promotes gut health and immune development in infants, while Bi-26™ is a beneficial bacterium found in breastfed infants.
  • The study used piglets to test the effects of 2'-FL and Bi-26™ on immune development, with results showing increased levels of certain cytokines in the serum of piglets receiving 2'-FL compared to those that did not.
  • Findings suggest that 2'-FL enhances cytokine responses without altering immune cell populations and that Bi-26™ can moderate the pro-inflammatory response in immune cells stimulated by LPS.
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The pathophysiology of multiple sclerosis (MS) remains poorly understood despite decades of tremendous research efforts. Advances in neuroradiography coupled with availability of unbiased approaches including spatial transcriptomics, proteomics, metabolomics, and lipidomics that are compatible with brain and fluid specimens from patients raise hope that discovery of novel disease drivers is on the horizon. Once thought to be little more than salty bathwater, our modern understanding of cerebrospinal fluid (CSF) suggests the CSF as a compelling, critical regulator of brain function in health and disease.

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Introduction: In recent decades, attendance to organized breast cancer screening has been decreasing in European countries. This could be partly due to an increase in the use of opportunistic screening. The aim of this study was to assess the coverage of imaging in and outside the screening program in Finland during the period of 1999-2018.

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This review examines the crucial roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological relevance of these changes. We highlight primary pathologies of the ChP, as well as their significance in neurologic disorders, including stroke, hydrocephalus, infectious diseases, and neurodegeneration.

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