Effect of integrated medicines management on quality of discharge medication information-a secondary endpoint in a randomized controlled trial.

Background: High-quality discharge information is important to promote patient safety when patients are transferred from hospital to primary care. Patients with multiple long-term conditions are especially vulnerable to insufficient transfer of medication information, as they use many medications and have complex interactions with the healthcare services. The aim of this study was to investigate the effect of integrated medicines management provided to hospitalized multimorbid patients on the quality of the discharge medication information.

Reliability of Digital Artery Palpation and Pulse Oximetry Waveform As Alternatives to Radial Pulse in the Assessment of Upper Limb Injuries.

Introduction: Radial pulse palpation is widely accepted as a gold standard clinical method to assess distal vascular perfusion of the upper limb. In some instances, the radial pulse may not be accessible due to splints, casts, or swelling, or the injury may be at the level or distal to the radial artery. Here, the authors assess two alternative methods of assessing perfusion of the hand more distally: palpation of the digital pulse and pulse oximetry (PO) waveform.

3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity.

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor microenvironment. Here, we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human pathology. Our findings unveil the functional maturation of this millimeter-sized model, showcasing the development of a hypoxic cancer core and an increased surface proliferation.

Traversing the land-sea interface: A climate change risk assessment of terrestrially breeding marine predators.

Terrestrially breeding marine predators have experienced shifts in species distribution, prey availability, breeding phenology, and population dynamics due to climate change worldwide. These central-place foragers are restricted within proximity of their breeding colonies during the breeding season, making them highly susceptible to any changes in both marine and terrestrial environments. While ecologists have developed risk assessments to evaluate climate risk in various contexts, these often overlook critical breeding biology data.