Grading systems and perineural invasion in oral squamous cell carcinoma - a disease-specific survival analysis.

Background: Oral squamous cell carcinoma (OSCC) is an aggressive cancer, with prognosis influenced by clinical variables as well grading systems and perineural invasion (PNI), which are associated to poorer outcomes, including higher rates of recurrence and metastasis. This study aims to evaluate OSCC using three grading systems and assess the impact of PNI and clinicopathologic parameters on patient survival.

Material And Methods: Eighty-one primary OSCC samples were analyzed.

Expression of ABCB1, ABCC1, and LRP in Mesenchymal Stem Cells from Human Amniotic Fluid and Bone Marrow in Culture-Effects of In Vitro Osteogenic and Adipogenic Differentiation.

Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into various lineages. They have also the potential to protect themselves against harmful stimuli to maintain their functional integrity. Drug resistance-related transporters such as ABCB1 (P-glycoprotein; P-gp), ABCC1 (MRP1; multidrug resistance-related Protein 1), and LRP (lung resistance protein) may protect MSCs against toxic substances such as chemotherapeutic agents.

Multiparameter analysis of small non-flying mammals' response to forest restoration post-bauxite mining in eastern Amazonia.

Bauxite mining has been caused severe changes in the natural ecosystems of the Amazon, but the restoration of these areas is mandatory by federal law in Brazil. The recolonization of fauna is crucial to establishing the ecological functions of recovering forests, and the small nonflying mammals can stand out in this process. Assessing taxonomic and functional diversity parameters, we demonstrated that in the early stages of forest recovery post-bauxite mining, between 6 and 11 years, it is possible to restore approximately 45% of the richness of small non-flying mammal species from the original habitats, that in this case were altered Primary Forests.

Simulated practice in the development of clinical reasoning in nursing students: A systematic review protocol.

is a pedagogical technique that replicates real-world scenarios in a controlled environment, enabling nursing students to engage in the teaching-learning process actively. While simulated practice is a growing pedagogical strategy, several studies have examined its strengths and limitations. However, evidence of its effectiveness in developing clinical reasoning skills among nursing students still needs to be improved.

Evaluation of the water quality monitoring program of Mountain Rivers located in a tropical protected atlantic Forest area (PARNASO, Brazil): are the impacts of the highway really assessed?

Road activities are recognized sources of pollution that affect the hydrochemistry of nearby water bodies. This study evaluated the Water Quality Monitoring Program in the Soberbo and Iconha rivers in the Guapi-Macacu watershed, which is affected by the BR-116 highway. The Rio-Teresópolis Concessionaire from 2009 to 2016 carried out quarterly sampling.