Publications by authors named "M S Kronenberg"
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-inhibitors and when they are needed is unknown.
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- Tomographic imaging of time-evolving samples is important but challenging, especially at the nanoscale due to limits in speed and resolution in current methods.
- A new dynamic nanotomography technique was developed that enhances imaging efficiency using sparse dynamic imaging and 4D tomography modeling.
- This technique significantly improves temporal resolution by 40 times and allows for detailed observations of the hydration process in polymer electrolyte fuel cell catalysts, aiding in the understanding and optimization of their performance.
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- Immune-related adverse events (irAEs) from immune checkpoint blockade (ICB) therapy affect many cancer patients, with their underlying causes not fully understood.
- Research identified a bio-active lipid called linoleoyl-lysophosphatidylcholine (LPC 18:2) that may play a key role in modulating these adverse events, with low levels of LPC 18:2 linked to the onset of severe irAEs.
- Supplementing LPC 18:2 in preclinical and human studies showed a reduction in harmful inflammation and neutrophil levels without detracting from the anti-tumor effectiveness of ICB therapy, suggesting it could enhance patient outcomes.
To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from patients with UC and controls. Here we identified colonic CD4 and CD8 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in several mouse models of autoimmune disease. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients.
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