Chemometric Model for Rapid Determination of Syringyl/Guaiacyl Ratio in Non-Wood by FT-NIR Spectroscopic Data.

The present study is to develop a cost-effective, non-destructive and rapid method for quantification of syringyl/guaiacyl (S/G) ratio content in non-wood lignin, which is based on FT-NIR spectroscopic data and chemometric modelling techniques. The S/G ratio in 22 non-wood lignins was determined by wet chemical method. Then the same samples were run with FT-NIR, and the spectroscopic data were pre-processed with Savitzky-Golay (S-G) on their 1st and 2nd derivatives.

1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY.

MraY, a bacterial enzyme crucial for the synthesis of peptidoglycans, represents a promising yet underexplored target for the development of effective antibacterial agents. Nature has provided several classes of nucleoside inhibitors of MraY and scientists have modified these structures further to obtain natural product-like inhibitors of MraY. The natural products and their synthetic analogs suffer from non-optimal efficacy, and the synthetic complexity of the structures renders the synthesis and structure-activity relationship (SAR) studies of these molecules particularly challenging.

A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh.

Background: Listeria monocytogenes is a foodborne pathogen that can lead to severe pregnancy outcomes. This study reports the clinical and genomic characteristics of a Listeria-mediated stillbirth identified in January 2022 through the Child Health and Mortality Prevention Surveillance (CHAMPS) project in Bangladesh. The Lm-BD-CHAMPS-01 isolate was recovered from the blood and cerebrospinal fluid (CSF) of a male stillborn.

A Comprehensive Analysis of Surgical Outcomes for Spinal Fractures in Patients With Ankylosing Spondylitis: A 13-Year Prospective Study.

Introduction: Ankylosing spondylitis (AS), a chronic inflammatory spondyloarthropathy affecting the spine, progressively leads to increased spinal stiffness. This condition increases the risk of spine fractures in patients, even from trivial injuries. The process of slow bone formation within the ligaments of the spine and the fusion of the spinal diarthrosis contribute to the most prominent symptom of progressive stiffness of joints, predominantly affecting the spine and sacroiliac joints.

Neuroanatomical distribution of endogenous huntingtin and its immunohistochemical relationships with STB/HAP1 in the adult mouse brain and spinal cord.

Huntingtin-associated protein 1 (HAP1) is an essential constituent of the stigmoid body (STB) and is known as a neuroprotective interactor with causal agents for several neurodegenerative disorders, including huntingtin (HTT) in Huntington's disease. Previous in vitro studies showed that compared to normal HTT, STB/HAP1 exhibited a higher binding affinity for mutant HTT. The detailed in vivo relationships of STB/HAP1 with endogenous HTT, however, have not been clarified yet.