siRNA-based therapy for overcoming drug resistance in human solid tumours; molecular and immunological approaches.

RNA interference (RNAi) is a primordial biological process that protects against external intrusion. SiRNA has the potential to selectively silence disease-related genes in a sequence-specific way, thus offering a promising therapeutic approach. The efficacy of siRNA-based therapies in cancer treatment has gained significant recognition due to multiple studies demonstrating its ability to effectively suppress cancer cells' growth and multiplication.

Topical Application of Dipyridamole and Roflumilast Combination Nanoparticles Loaded Nanoemulgel for the Treatment of Psoriasis in Rats.

Background: Phosphodiesterase-4 is an enzyme that regulates immune responses and contributes to the development of psoriasis. Dipyridamole and roflumilast function as phosphodiesterase-4 inhibitors, reducing pro-inflammatory cytokine expression. The aim was to evaluate the anti-psoriatic effect of the topical administration of dipyridamole and roflumilast nanoemulgel combination on imiquimod-induced psoriasiform skin inflammation in rats.

Insights into the pharmaceutical properties and in silico study of novel hydrazone derivatives.

It has been established that the Hydrazone derivatives have important pharmacological effects. In the first step, hydrazine (NHNH) reacts with a compound containing a carbonyl group (C = O) in the presence of ethanol and heat, leading to the formation of hydrazone compound (H1). The second step is the formation of the Schiff base (H2) by the reaction of compound (H1) with indole, ethanol, and acetic acid, which contain a double bond (C = N).

Organ-specific renal tissue damage manifested by single-walled carbon-nanotubes and single-walled carbon-nanotubes-silver-titania nanocomposite: Cellular toxicity at high doses.

Background: Single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) can pose risks in biological systems leading to harmful effects, such as, reactive oxygen species (ROS) formation, DNA damage, mitochondrial dysfunction, and ultimately, the cell death through apoptosis.

Objectives: The study assessed the nephrotoxicity of the SWCNTs and SWCNTs-Ag-TiO nanocomposites through in vitro and in vivo experiments, assessing oxidative stress, genotoxicity, and safety for biomedical applications.

Methodology: In vitro, HK-2 cell lines were utilized to evaluate the effects of nanomaterials on cellular activity, apoptosis, ROS generation, and micronuclei formations.