Publications by authors named "M S Holanda-Pena"
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
View Article and Find Full Text PDFCharacteristics and management of patients with SARS-CoV2 infection admitted to pediatric intensive care units: Data analysis of the Spanish national multicenter registry.
Pediatr Pulmonol
October 2023
Introduction: The purpose of this study is to describe the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) disease characteristics and management in children admitted to the pediatric intensive care units (PICU).
Methods: The present study was based on a national multicentric prospective registry including PICU patients with SARS-CoV2 infection or symptoms of multisystem inflammatory syndrome in children (MIS-C).
Results: A total of 298 patients were admitted to 41 different Spanish PICUs.
Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain.
Crit Care
November 2020
Article Synopsis
- The study examines children admitted to Pediatric Intensive Care Units (PICUs) with Multisystem Inflammatory Syndrome (MIS-C) related to COVID-19, comparing their characteristics to those with other COVID-19-related conditions.
- Of the 74 children recruited, 61% met MIS-C criteria, showing they were older and more likely to have no significant prior medical history than non-MIS-C patients.
- MIS-C patients displayed a higher prevalence of symptoms like fever, diarrhea, and shock, alongside differing laboratory results, and were treated differently than non-MIS-C patients, receiving more corticosteroids and fewer invasive ventilation treatments.
The role of Critical Care Medicine in Spain requires continuous revision and reflection. We have values and strengths that are evidenced in our daily work and by their important effects in routine hospital activity. Other medical specialties seeking to assume activities referred to critical patient care, as well as a number of other circumstances, may have a negative impact upon our routine duties.
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