Optimization of performance of Dutch newborn screening for cystic fibrosis.

Background: Dutch newborn screening (NBS) for Cystic Fibrosis (CF) introduced in 2011 showed a sensitivity of 90% and a positive predictive value (PPV) of 63%. We describe a study including an optimization phase and evaluation of the modified protocol.

Methods: Dutch protocol consists of four steps: determination of immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP), DNA analysis by INNO-LiPA and extended gene analysis (EGA).

Gravity-driven membrane filtration with compact second-life modules daily backwashed: An alternative to conventional ultrafiltration for centralized facilities.

Gravity-driven membrane (GDM) filtration is a strategic alternative to conventional ultrafiltration (UF) for the resilient production of drinking water via ultrafiltration when resources become scarce, given the low dependency on energy and chemicals, and longer membrane lifetime. Implementation at large scale requires the use of compact and low-cost membrane modules with high biopolymer removal capacity. We therefore evaluated (1) to what extent stable flux can be obtained with compact membrane modules, i.

IJES Self-Study on Participants' Sex in Exercise Science: Sex-Data Gap and Corresponding Author Survey.

A sex-data gap exists between females and males within the sport and exercise science literature, and implications are far-reaching. The purpose of this work was to (a) heed recent calls and scrutinize data from within IJES to address the gap and (b) gain insight on self-identified sex of IJES corresponding authors. The present self-study included all published manuscripts from 2008 through 2021.

Comment on Jones et al. Application of a Novel Algorithm for Expanding Newborn Screening for Inherited Metabolic Disorders across Europe. 2022, , 20.

With innovations in both the screening methodologies and treatment of diseases, newborn screening (NBS) programmes are confronted with an increasing number of candidate diseases [...

Efficacy of Army Combat Fitness Test 12-Week Virtual Exercise Program.

Introduction: The Army Combat Fitness Test (ACFT) is the fitness assessment used by the Army launched in April of 2022. The ACFT consists of six physically demanding motor movements that parallel to the stressors experienced by the modern-day combat soldier. The aim of this study is to determine the efficacy of a 12-week virtual exercise program on the individual and their overall ACFT scores.