CALR frameshift mutation detection in myeloproliferative neoplasms by microfluidic chip analysis.

Background: CALR mutation analysis is routinely used to diagnose BCR/ABL1-negative myeloproliferative neoplasms. The 2 most common CALR mutations are a 52-base pair (bp) deletion and a 5-bp insertion, which account for approximately 85% of cases.

Methods: To evaluate our new microfluidic chip assay, we tested CALR mutant and wild-type specimens that were previously analyzed using conventional methods at a reference laboratory.

The efficacy of Pilates-based exercises on rectus abdominis engagement in comparison with the FITNESSGRAM in Collegiate dancers.

Engagement of the core abdominal muscles is essential to maintain proper alignment, technique, and safety. This study compared the muscular amplitude of the upper and lower rectus abdominis muscles' EMG during six Pilates-based abdominal exercises with the FITNESSGRAM in order to determine which may be more effective for dancers. A sphygmomanometer is used as a training tool for neutral pelvis stability; therefore this study also investigated the muscle activation of the Pilates-based exercises with and without the use of a sphygmomanometer to determine which would be more effective in muscular engagement.

Randomized Controlled Trial of a Virtually Delivered Exercise and Stress Management Program to Improve Physical Performance of Hematopoietic Cell Transplant Survivors.

Purpose: Because of advances in hematopoietic cell transplant (HCT), meeting the long-term health needs of increasing numbers of HCT survivors remains challenging. This multicenter trial aimed to assess the short- and long-term effects of an exercise and mindfulness intervention delivered by telehealth.

Methods: One hundred thirty-nine participants >6 months post-HCT were randomly assigned 1:1 to a 6-week personalized exercise and mindfulness training with three motivation sessions at 3-6 months via an online meeting platform or usual care.