Publications by authors named "M S Freiberg"
People with HIV (PWH) on antiretroviral therapy (ART) often gain weight, which increases their risk of type 2 diabetes and cardiovascular disease. The role of DNA methylation (DNAm) markers in obesity among PWH is understudied. This research explores the relationship between body mass index (BMI) and epigenetic patterns to better understand and manage obesity-related risks in PWH.
View Article and Find Full Text PDFRationale: Incidence rates for pulmonary hypertension using diagnostic data in patients with cardiopulmonary disease are not known.
Objectives: To determine incidence rates of, risk factors for, and mortality hazard associated with pulmonary hypertension among patients referred for transthoracic echocardiography.
Methods: Retrospective cohort study using data from the Veterans Health Administration (1999-2020) and Vanderbilt University Medical Center (1994-2020).
Article Synopsis
- * Researchers conducted single-trait epigenome-wide association studies (EWAS) focusing on three inflammatory markers in a study of 920 male PWH, predominantly Black and averaging 51 years old.
- * By utilizing multi-trait EWAS methods, they discovered numerous DNAm sites associated with inflammation, many of which were not identified in single-trait analyses, highlighting crucial inflammation-related genes and pathways that could help address chronic inflammation in PWH.
Introduction: Incidence rates (IRs) of RV dysfunction (RVD) are unknown. We examined the rates, risk factors, and heart failure (HF) hospitalization hazard associated with incident RVD in patients referred for Transthoracic Echocardiogram (TTE).
Methods: In this retrospective cohort study, we extracted tricuspid regurgitant velocity (TRV) and tricuspid annular systolic plane excursion (TAPSE) from TTEs at Vanderbilt (2010-2023).
Rationale: Incidence rates for pulmonary hypertension using diagnostic data in patients with cardiopulmonary disease are not known.
Objectives: To determine incidence rates of, risk factors for, and mortality hazard associated with pulmonary hypertension among patients referred for transthoracic echocardiography Methods: Retrospective cohort study using data from the Veterans Health Administration (1999-2020) and Vanderbilt University Medical Center (1994-2020). Pulmonary hypertension was defined as pulmonary artery systolic pressure >35mmHg with prevalent cases excluded.