Publications by authors named "M S Filigenzi"
Mass spectrometry in animal health laboratories: recent history, current applications, and future directions.
J Vet Diagn Invest
November 2024
Article Synopsis
- Mass spectrometry (MS) has been a key method in analytical chemistry, but its use in animal health labs has been limited due to high costs.
- Since around 2020, there has been a notable increase in the adoption of MS in these labs, benefiting areas like veterinary toxicology and bacteriology.
- New MS techniques and innovations are emerging, promising to expand its applications to other fields such as virology and pathology.
Monofluoroacetate is a highly lethal toxin that causes death by inhibiting cellular adenosine triphosphate (ATP) production. The heart and brain are the primary target organs. Acute death is attributed to cardiac fibrillation and/or convulsions.
View Article and Find Full Text PDFFour alpine goats developed diarrhea soon after the owner placed plant clippings believed to be yellow oleander () into their pen on a suburban property near Palm Desert, CA, USA. A 1-y-old female goat died suddenly ~1 h after eating the plant clippings and was submitted to the San Bernardino Branch of the California Animal Health and Food Safety Laboratory System for postmortem examination. The main autopsy and histopathologic findings were myocardial hemorrhage and necrosis, consistent with cardiac glycoside intoxication.
View Article and Find Full Text PDFAnti-coagulant rodenticides (ARs) are commonly utilized for controlling rodent populations; however, non-target companion and wildlife animals are also exposed. A method was developed for quantitation of seven ARs (chlorophacinone, coumachlor, bromadiolone, brodifacoum, difethialone, diphacinone and warfarin) and dicoumarol (a naturally occurring anti-coagulant) in animal serum. Analytes were extracted with 10% (v/v) acetone in methanol and analyzed by reverse phase high-performance liquid chromatography-tandem mass spectrometry using electrospray ionization (negative mode) combined with multiple reaction monitoring.
View Article and Find Full Text PDFBackground: Human grayanotoxin poisoning is distinctly uncommon in North America, as the predominant source of human exposure is honey made by bees pollinating rhododendron species in the Mediterranean. We present a case of confirmed grayanotoxin poisoning from honey imported from Turkey.
Case Report: A 61-year-old man developed nausea, lightheadedness, and lost consciousness.